Maren S, Baudry M, Thompson R F
Neurosciences Program, University of Southern California, Los Angeles 90089-2520.
Neuroreport. 1991 May;2(5):239-42. doi: 10.1097/00001756-199105000-00006.
Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel. Recent studies have suggested that the binding properties of these drugs to the NMDA receptor in-vitro are different. In the present study, the effects of ketamine and MK-801 on the induction of long-term potentiation (LTP) were compared at perforant path--granule cell synapses in anaesthetized rats. LTP was observed in animals treated with either saline or MK-801, but not in those treated with ketamine. These results reveal that ketamine and MK-801 differentially modulate the induction of LTP, and we propose that this differential modulation may be related to the different binding properties of the drugs.
氯胺酮和MK-801是与苯环己哌啶（PCP）类似的N-甲基-D-天冬氨酸（NMDA）受体非竞争性拮抗剂，它们会对NMDA受体偶联通道产生使用依赖性阻断作用。最近的研究表明，这些药物在体外与NMDA受体的结合特性有所不同。在本研究中，比较了氯胺酮和MK-801对麻醉大鼠穿孔通路-颗粒细胞突触处长期增强（LTP）诱导的影响。在用生理盐水或MK-801处理的动物中观察到了LTP，但在用氯胺酮处理的动物中未观察到。这些结果表明，氯胺酮和MK-801对LTP诱导的调节存在差异，我们认为这种差异调节可能与药物的不同结合特性有关。
