de Almeida Patrícia Del Vigna, Grégio Ana Maria Trindade, Brancher João Armando, Ignácio Sérgio Aparecido, Machado Maria Angela Naval, de Lima Antônio Adilson Soares, Azevedo Luciana Reis
Department of Stomatology, School of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):58-65. doi: 10.1016/j.tripleo.2007.11.008. Epub 2008 Mar 10.
To evaluate the effect of psychotropics on stimulated salivary flow rate (SSFR), total proteins, urea and calcium concentration, alpha-amylase activity, pH, saliva buffer capacity (SBC), and the prevalence of xerostomia in psychotropic users and its relationship with low SSFR and/or hyposalivation.
Thirty-three subjects were allocated to 4 groups: I (control): II (psychotropic users); III (subjects of group II using only selective serotonin reuptake inhibitors [SSRIs]); and IV (subjects of group II using SSRIs at recommended initial dose). The SBC was obtained by titrimetry and salivary composition by colorimetric method.
Group II presented a significant decrease (P = .0203), of 33.85% in SSFR compared with group I. Mean SSFR values in groups III and IV showed no significant difference compared with control group (P > .05). Xerostomia was observed in 37.50%, 38.46%, and 50% of subjects in groups II, III, and IV, respectively. Biochemical composition, pH, and SBC were not significantly affected (P > .05) by the use of psychotropics.
Xerostomia was associated with a decrease in SSFR and not with alterations in biochemical composition. Even when using the latest-generation drugs, there were complaints of xerostomia associated with decrease in SSFR.
评估精神药物对刺激唾液流速（SSFR）、总蛋白、尿素和钙浓度、α淀粉酶活性、pH值、唾液缓冲能力（SBC）的影响，以及精神药物使用者口干症的患病率及其与低SSFR和/或唾液分泌减少的关系。
33名受试者被分为4组：I组（对照组）；II组（精神药物使用者）；III组（II组中仅使用选择性5-羟色胺再摄取抑制剂[SSRI]的受试者）；IV组（II组中按推荐初始剂量使用SSRI的受试者）。通过滴定法获得SBC，通过比色法获得唾液成分。
与I组相比，II组的SSFR显著降低（P = 0.0203），降低了33.85%。III组和IV组的平均SSFR值与对照组相比无显著差异（P > 0.05）。II组、III组和IV组分别有37.50%、38.46%和50%的受试者出现口干症。精神药物的使用对生化成分、pH值和SBC没有显著影响（P > 0.05）。
口干症与SSFR降低有关，而与生化成分改变无关。即使使用最新一代药物，仍有与SSFR降低相关的口干症主诉。
