Mattioli Tatiana Maria Folador, Koubik Ana Cláudia, de Oliveira Ribas Marina, França Beatriz Helena Sottile, Brancher João Armando, de Lima Antonio Adilson Soares
Departments of Stomatology, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
J Pediatr Hematol Oncol. 2010 Mar;32(2):e46-9. doi: 10.1097/MPH.0b013e3181c29c11.
Fanconi anemia (FA) is a genetic disease characterized by a chromosomal instability that develops a progressive pancitopenia, leukemia, and/or solid tumors. Nevertheless, it is unknown if this illness induces changes on the salivary gland parenchyma and function. The aim of this study was to assess the stimulated salivary flow rate (SSFR) and calcium, urea, total protein, and amylase levels in saliva of FA patients.
Stimulated whole saliva was collected from 34 randomly selected FA patients and 34 age-matched and sex-matched controls. Both samples were analyzed for salivary flow rate, calcium, urea, total proteins, and amylase. The SSFR was analyzed by gravimetric method and calcium, urea, total protein, and amylase concentrations were realized by chemistry tests.
Mean values of SSFR for experimental and control groups were, respectively, 0.5 mL/min and 0.8 mL/min (P<0.05). Calcium concentration was 36% (P<0.05) and urea concentration was 21% (P<0.01) lower in the FA group saliva compared with saliva from the controls. The saliva concentration of amylase was almost equal in both groups.
FA patients may exhibit significant changes in SSFR, calcium, and urea concentration of saliva.
范可尼贫血（FA）是一种遗传性疾病，其特征为染色体不稳定，可发展为进行性全血细胞减少、白血病和/或实体瘤。然而，尚不清楚这种疾病是否会引起唾液腺实质和功能的变化。本研究的目的是评估FA患者唾液的刺激唾液流速（SSFR）以及钙、尿素、总蛋白和淀粉酶水平。
从34例随机选择的FA患者以及34例年龄和性别匹配的对照者中收集刺激后的全唾液。对两组样本均进行唾液流速、钙、尿素、总蛋白和淀粉酶分析。SSFR采用重量法分析，钙、尿素、总蛋白和淀粉酶浓度通过化学检测确定。
实验组和对照组的SSFR平均值分别为0.5 mL/分钟和0.8 mL/分钟（P<0.05）。与对照组唾液相比，FA组唾液中的钙浓度降低了36%（P<0.05），尿素浓度降低了21%（P<0.01）。两组的淀粉酶唾液浓度几乎相等。
FA患者的唾液SSFR、钙和尿素浓度可能会出现显著变化。
