Mollard Pascal, Woorons Xavier, Antoine-Jonville Sophie, Jutand Luce, Richalet Jean Paul, Favret Fabrice, Pichon Aurélien
Université Paris 13, UFR SMBH, STAPS, Laboratoire Réponses Cellulaires et Fonctionnelles à l'hypoxie, UPRES EA 2363, 74 rue Marcel Cachin, 93017 Bobigny Cedex, France.
Respir Physiol Neurobiol. 2008 Apr 30;161(2):167-73. doi: 10.1016/j.resp.2008.01.006. Epub 2008 Feb 3.
We assessed the ability of the oxygen uptake efficiency slope, whether calculated on 100 and 80% of maximal exercise test duration (OUES(100) and OUES(80)), to identify the change in cardiorespiratory capacities in response to hypoxia in subjects with a broad range of V(O2 peak). Four maximal exercise tests were performed in trained (T) and untrained subjects (UT) in normoxia and at 1000, 2500 and 4500 m. The mean reductions in maximal exercise capacities at 4500 m were the same in T subjects for V(O2 peak) (-30%), OUES(80) (-26%) and OUES(100) (-26%) whereas in UT subjects only OUES(100) (-14%), but not OUES(80) (-20%), was lower compared with V(O2 peak) (-21%, p<0.05). OUES(100) and OUES(80) were correlated with V(O2 peak) and the ventilatory anaerobic threshold in both groups. Multiple regression analyses showed that V(O2 peak), OUES(100) and OUES(80) were significantly linked to O(2) arterial-venous difference. The OUES(80) could be considered as an interesting sub-maximal index of cardiorespiratory fitness in normal or hypoxemic subjects unable to reach V(O2 peak).
我们评估了摄氧效率斜率（无论按最大运动测试持续时间的100%和80%计算，即OUES(100)和OUES(80)）识别不同最大摄氧量（V̇O₂peak）受试者对低氧反应时心肺功能变化的能力。在常氧环境以及海拔1000米、2500米和4500米的环境下，对训练有素的受试者（T）和未经训练的受试者（UT）进行了四项最大运动测试。在4500米高度时，T组受试者的最大运动能力平均下降幅度对于V̇O₂peak为（-30%）、OUES(80)为（-26%）、OUES(100)为（-26%）；而在UT组受试者中，只有OUES(100)（-14%）相较于V̇O₂peak（-21%，p<0.05）有所下降，OUES(80)（-20%）则未下降。两组中OUES(100)和OUES(80)均与V̇O₂peak和通气无氧阈相关。多元回归分析表明，V̇O₂peak、OUES(100)和OUES(80)均与动脉-静脉氧分压差显著相关。对于无法达到V̇O₂peak的正常或低氧受试者，OUES(80)可被视为一个有趣的次最大心肺适能指标。
