Chen Xianping, van Pée Karl-Heinz
Biomedical Engineering Centre, Guilin University of Electronic Technology, Guilin 541004, China.
Acta Biochim Biophys Sin (Shanghai). 2008 Mar;40(3):183-93. doi: 10.1111/j.1745-7270.2008.00390.x.
The understanding of enzymatic incorporation of halogen atoms into organic molecules has increased during the last few years. Two novel types of halogenating enzymes, flavin-dependent halogenases and alpha-ketoglutarate-dependent halogenases, are now known to play a significant role in enzyme-catalyzed halogenation. The recent advances on the halogenating enzymes RebH, SyrB2, and CytC3 have suggested some new mechanisms for enzymatic halogenations. This review concentrates on the occurrence, catalytic mechanisms, and biotechnological applications of the halogenating enzymes that are currently known.
在过去几年中，人们对酶促卤素原子掺入有机分子的理解有所增加。现在已知两种新型卤化酶，即黄素依赖性卤化酶和α-酮戊二酸依赖性卤化酶，在酶催化卤化反应中发挥着重要作用。卤化酶RebH、SyrB2和CytC3的最新进展提出了一些酶促卤化的新机制。本综述集中于目前已知的卤化酶的存在、催化机制及生物技术应用。
