Tamam Banu, Taşdemir Nebahat, Tamam Yusuf
Diyarbakir Devlet Hastanesi, Nöroloji AD, Diyarbakir.
Turk Psikiyatri Derg. 2008 Spring;19(1):46-56.
The aim of this study was to determine the prevalence of post-stroke dementia (PSD) and its possible clinical and sociodemographic risk factors 3 months after the index stroke episode.
Among 147 patients who were hospitalized in the inpatient neurology clinic of Dicle University Faculty of Medicine with a diagnosis of stroke, 106 that met the inclusion criteria were included in the study 3 months after the index stroke. All patients underwent a detailed systemic and neurological examination, as well as a clinical interview in an effort to determine the sociodemographic features, and both vascular and non-vascular risk factors of stroke. Routine laboratory examinations and cranial imaging (computed tomography [CT] or magnetic resonance imaging [MRI]) were also conducted. The functional, clinical, and cognitive status of the patients were evaluated at the time of hospitalization and 3 months later with the Barthel Index, NIH Stroke Scale (NIHSS), and Mini Mental State Examination (MMSE), respectively.
Of the 106 patients included in the study, 32 (30.2%) were diagnosed with PSD. Multivariate analyses revealed that increased age, presence of atrial fibrillation, multiple brain lesions, and cognitive and functional status during hospitalization predicted the development of PSD in this group of patients.
The results corroborate previous findings that PSD is a common complication of stroke. Early recognition and treatment of PSD risk factors will definitely diminish the burden of stroke on society and help to improve patient quality of life.
本研究旨在确定首发卒中事件3个月后卒中后痴呆(PSD)的患病率及其可能的临床和社会人口统计学风险因素。
在147名因卒中诊断入住迪克莱大学医学院神经内科病房的患者中,106名符合纳入标准的患者在首发卒中3个月后纳入研究。所有患者均接受了详细的全身和神经系统检查以及临床访谈,以确定社会人口统计学特征以及卒中的血管和非血管风险因素。还进行了常规实验室检查和头颅成像(计算机断层扫描[CT]或磁共振成像[MRI])。分别在住院时和3个月后使用巴氏指数、美国国立卫生研究院卒中量表(NIHSS)和简易精神状态检查表(MMSE)对患者的功能、临床和认知状态进行评估。
在纳入研究的106名患者中,32名(30.2%)被诊断为PSD。多变量分析显示,年龄增加、存在心房颤动、多处脑损伤以及住院期间的认知和功能状态可预测该组患者PSD的发生。
结果证实了先前的研究结果,即PSD是卒中的常见并发症。早期识别和治疗PSD风险因素肯定会减轻卒中对社会的负担,并有助于提高患者生活质量。