Wang J Z, Chen M E, Xu Y Q
Third Teaching Hospital, Third Military Medical College, Chongqing.
Zhong Xi Yi Jie He Za Zhi. 1991 Jul;11(7):420-1, 390.
Both angiotensin II (AII) and atrial natriuretic polypeptide (ANP) are related to the function of blood vessels, but differ in their actions. The authors observed the effect of Salvia miltiorrhiza Co. (SMC) on the activities of AII and ANP in rabbits by radioimmunoassay. It was found that the concentration of AII and ANP in plasma were significantly lower (P less than 0.05), and slightly lower in brain and atrial (P greater than 0.05) in SMC group than in control group. It indicated that the effect of SMC on blood vessels is related to changes of AII and ANP, and that the difference of peptide changes in brain and plasma might be due to the blood-brain barrier.
血管紧张素II（AII）和心钠素（ANP）均与血管功能有关，但作用有所不同。作者采用放射免疫分析法观察了丹参对家兔AII和ANP活性的影响。结果发现，丹参组血浆中AII和ANP的浓度显著低于对照组（P<0.05），脑和心房中的浓度略低于对照组（P>0.05）。这表明丹参对血管的作用与AII和ANP的变化有关，脑和血浆中肽变化的差异可能是由于血脑屏障所致。
