Stierle Andrea A, Stierle Donald B, Patacini Brianna
Department of Chemistry and Geochemistry, Montana Tech of the University of Montana, Butte, MT 59701, USA.
J Nat Prod. 2008 May;71(5):856-60. doi: 10.1021/np0705054. Epub 2008 Mar 11.
We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.
我们之前报道过从蒙大拿州比尤特市伯克利矿坑湖分离出的一种深水红色青霉中得到的几种新型生物活性聚酮-萜类杂合代谢产物。在本文中，我们报道了从该真菌提取物中分离出的四种新酰胺类化合物，即伯克利酰胺A-D（1、4、5、7）。通过对核磁共振数据的分析、化学衍生化以及将它们的光谱数据与已知化合物的光谱数据进行比较，推断出了这些化合物的结构。
