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极端环境真菌来源的新型天然产物。

Novel Natural Products from Extremophilic Fungi.

机构信息

Gene Engineering and Biotechnology Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China.

出版信息

Mar Drugs. 2018 Jun 4;16(6):194. doi: 10.3390/md16060194.

DOI:10.3390/md16060194
PMID:29867059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6025453/
Abstract

Extremophilic fungi have been found to develop unique defences to survive extremes of pressure, temperature, salinity, desiccation, and pH, leading to the biosynthesis of novel natural products with diverse biological activities. The present review focuses on new extremophilic fungal natural products published from 2005 to 2017, highlighting the chemical structures and their biological potential.

摘要

极端真菌已被发现发展出独特的防御机制,以在压力、温度、盐度、干燥和 pH 值等极端条件下生存,从而导致具有多种生物活性的新型天然产物的生物合成。本综述重点介绍了 2005 年至 2017 年期间发表的新的极端真菌天然产物,强调了它们的化学结构和生物潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1708b3a99f97/marinedrugs-16-00194-g051a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/dba00c24de0c/marinedrugs-16-00194-g034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/db5dee965e63/marinedrugs-16-00194-g036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/eb70faf67393/marinedrugs-16-00194-g038a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1a2204926ec1/marinedrugs-16-00194-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1198b8b19510/marinedrugs-16-00194-g042.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/c30d6e9f3650/marinedrugs-16-00194-g043.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/0de5ae019999/marinedrugs-16-00194-g044.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/a4062e023fec/marinedrugs-16-00194-g045.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/f077693bb28f/marinedrugs-16-00194-g046.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1f29177b30f7/marinedrugs-16-00194-g047.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/62feca1d38e4/marinedrugs-16-00194-g048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/8c46cf4bdca2/marinedrugs-16-00194-g049.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/b06c3c441162/marinedrugs-16-00194-g050a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1708b3a99f97/marinedrugs-16-00194-g051a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/dba00c24de0c/marinedrugs-16-00194-g034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/db5dee965e63/marinedrugs-16-00194-g036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/eb70faf67393/marinedrugs-16-00194-g038a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1a2204926ec1/marinedrugs-16-00194-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1198b8b19510/marinedrugs-16-00194-g042.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/c30d6e9f3650/marinedrugs-16-00194-g043.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/0de5ae019999/marinedrugs-16-00194-g044.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/a4062e023fec/marinedrugs-16-00194-g045.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/f077693bb28f/marinedrugs-16-00194-g046.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1f29177b30f7/marinedrugs-16-00194-g047.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/62feca1d38e4/marinedrugs-16-00194-g048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/8c46cf4bdca2/marinedrugs-16-00194-g049.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/b06c3c441162/marinedrugs-16-00194-g050a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/6025453/1708b3a99f97/marinedrugs-16-00194-g051a.jpg

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2
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3
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4
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Front Plant Sci. 2023 Mar 17;14:1142212. doi: 10.3389/fpls.2023.1142212. eCollection 2023.
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