Iida Motoo, Ooi Takashi, Kito Keijiro, Yoshida Sanae, Kanoh Kaneo, Shizuri Yoshikazu, Kusumi Takenori
Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.
Org Lett. 2008 Mar 6;10(5):845-8. doi: 10.1021/ol7029867. Epub 2008 Feb 1.
Three novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium minioluteum strain. Their structures were determined by NMR spectroscopic analyses and X-ray crystallography. The proposed biosynthetic pathway including a unique retro-Claisen migration of methyl carbonate correlates the three compounds with berkeleydione and berkeleytrione.
从一株微小青霉菌株中分离出三种新型杂合聚酮-萜类代谢产物。通过核磁共振光谱分析和X射线晶体学确定了它们的结构。所提出的生物合成途径包括碳酸甲酯独特的逆克莱森重排，将这三种化合物与伯克利二酮和伯克利三酮联系起来。
