Witters P, Freson K, Verslype C, Peerlinck K, Hoylaerts M, Nevens F, Van Geet C, Cassiman D
Laboratory of Hepatology, Department of Pediatrics, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
Aliment Pharmacol Ther. 2008 Jun 1;27(11):1017-29. doi: 10.1111/j.1365-2036.2008.03674.x. Epub 2008 Mar 5.
The liver plays a central role in coagulation and fibrinolysis but is also closely intertwined with the function and number of blood platelets.
To describe and integrate all literature concerning blood platelets and liver disease by performing a thorough literature research.
A thorough literature research on 'blood platelets' and 'liver disease' was performed.
Thrombocytopenia is a marked feature of chronic liver disease and cirrhosis. Traditionally, this thrombocytopenia was attributed to passive platelet sequestration in the spleen. More recent insights suggest an increased platelet breakdown and to a lesser extent decreased platelet production plays a more important role. Besides the reduction in number, other studies suggest functional platelet defects. This platelet dysfunction is probably both intrinsic to the platelets and secondary to soluble plasma factors. It reflects not only a decrease in aggregability, but also an activation of the intrinsic inhibitory pathways. The net effect, finally, is a decreased platelet function in the various types of chronic liver diseases and cirrhosis. Finally, recent data suggest that platelets are not only affected by but can also contribute to the liver disease process, as for instance, in viral hepatitis and cholestatic liver disease.
Platelet research in liver disease is a growing area of investigation and could provide new pathophysiological insights.
肝脏在凝血和纤维蛋白溶解过程中起核心作用，但也与血小板的功能和数量密切相关。
通过全面的文献研究，描述并整合所有关于血小板与肝脏疾病的文献。
对“血小板”和“肝脏疾病”进行了全面的文献研究。
血小板减少是慢性肝病和肝硬化的显著特征。传统上，这种血小板减少归因于脾脏对血小板的被动扣押。最近的研究表明，血小板破坏增加以及血小板生成减少（程度较轻）起着更重要的作用。除了数量减少外，其他研究表明存在功能性血小板缺陷。这种血小板功能障碍可能既是血小板内在的，也是继发于可溶性血浆因子的。它不仅反映了聚集性的降低，还反映了内在抑制途径的激活。最终的净效应是各类慢性肝病和肝硬化中血小板功能降低。最后，最近的数据表明，血小板不仅受肝脏疾病过程影响，也能对其产生影响，例如在病毒性肝炎和胆汁淤积性肝病中。
肝脏疾病中的血小板研究是一个不断发展的研究领域，可能会提供新的病理生理学见解。
