Wang L S, Bai M Y
Department of Cardiology, Great Wall Hospital, Beijing.
Chin Med J (Engl). 1991 Aug;104(8):645-8.
To compare the efficacy of new calcium blocker nitrendipine and ACE-inhibitor captopril on the regression of hypertensive left ventricular hypertrophy (LVH), 134 hypertensive subjects with LVH were divided randomly into two groups. 2DE, M-mode and pulsed Doppler echocardiography was used to measure the left ventricular structure and function. In the nitrendipine group (n = 67, mean age 48 +/- 11 years), nitrendipine (20-40 mg/day) was administered for 24 months, and in the captopril group (n = 67, mean age 47 +/- 12 years), captopril (75-150 mg/day) was also given for 24 months. Blood pressure decreased significantly in all the patients. In the nitrendipine group, the thickness of the interventricular septum (IVST) and the posterior wall of the left ventricle (PWT) as well as the left ventricular mass index (LVMI) decreased by 20.3%, 15.5% and 25.7% (P less than 0.01) respectively. The cardiac index (CI), left ventricular ejection fraction (EF) and fractional shortening (FS) remained unchanged. The early peak filling velocity (E, 0.64 +/- 0.15 to 0.86 +/- 0.22, P less than 0.01) of the mitral valve and E to late peak filling velocity ratio (E/A, 0.88 +/- 0.20 to 1.31 +/- 0.31, P less than 0.01) increased significantly. In the captopril group, IVST, PWT, and LVMI were 20%, 17.1% and 23.6% respectively (P less than 0.01). CI (2.6 +/- 0.5 to 3.7 +/- 0.6L/min/m, P less than 0.01) and EF (60 +/- 4 to 78 +/- 6%, P less than 0.01) increased. Both E and E/A were elevated in a similar degree as in the nitrendipine group.(ABSTRACT TRUNCATED AT 250 WORDS)
为比较新型钙通道阻滞剂尼群地平和血管紧张素转换酶抑制剂卡托普利对高血压左心室肥厚（LVH）消退的疗效，将134例伴有LVH的高血压患者随机分为两组。采用二维超声心动图、M型超声心动图和脉冲多普勒超声心动图测量左心室结构和功能。尼群地平组（n = 67，平均年龄48±11岁）给予尼群地平（20 - 40 mg/天）治疗24个月，卡托普利组（n = 67，平均年龄47±12岁）给予卡托普利（75 - 150 mg/天）治疗24个月。所有患者血压均显著下降。尼群地平组室间隔厚度（IVST）、左心室后壁厚度（PWT）以及左心室质量指数（LVMI）分别下降了20.3%、15.5%和25.7%（P < 0.01）。心脏指数（CI）、左心室射血分数（EF）和缩短分数（FS）保持不变。二尖瓣早期峰值充盈速度（E，从0.64±0.15增至0.86±0.22，P < 0.01）以及E/A比值（从0.88±0.20增至1.31±0.31，P < 0.01）显著升高。卡托普利组IVST、PWT和LVMI分别下降了20%、17.1%和23.6%（P < 0.01）。CI（从2.6±0.5增至3.7±0.6L/min/m，P < 0.01）和EF（从60±4增至78±6%，P < 0.01）升高。E和E/A升高程度与尼群地平组相似。（摘要截断于250字）
