Mahoney M C, Michalek A M
Bureau of Cancer Epidemiology, New York State Department of Health, Albany 12237-0683.
Int J Epidemiol. 1991 Jun;20(2):323-7. doi: 10.1093/ije/20.2.323.
A meta-analytic approach was used to summarize studies of cancer incidence among Native populations in the United States and Canada. Native males and females were found to have a significantly lower incidence of cancer for all sites combined. Among Native males, kidney cancer was found to exhibit significantly elevated incidence, while significantly lower incidence was found for cancers of the colon, lung, and prostate, and for lymphomas and leukaemias. Native females were found to have significantly elevated incidence for cancers of the gallbladder, cervix, and kidney, while significantly decreased incidence was found for cancers of the colon, breast and uterus, and for lymphomas. The use of meta-analysis to integrate the findings from these studies allowed the identification of subtle differences in cancer incidence. Although these findings are not definitive, they overcome the limited numbers of site-specific cancers reported in many previous studies and are suggestive of general patterns of cancer incidence among Native populations. In addition, these results may be useful in indicating directions for future research involving specific cancer sites with elevated incidence.
采用荟萃分析方法总结美国和加拿大原住民人群癌症发病率的研究。结果发现，原住民男性和女性所有部位癌症的综合发病率显著较低。在原住民男性中，肾癌发病率显著升高，而结肠癌、肺癌和前列腺癌以及淋巴瘤和白血病的发病率则显著降低。原住民女性胆囊癌、宫颈癌和肾癌的发病率显著升高，而结肠癌、乳腺癌和子宫癌以及淋巴瘤的发病率则显著降低。通过荟萃分析整合这些研究结果，能够识别出癌症发病率的细微差异。尽管这些发现并非定论，但它们克服了许多先前研究中特定部位癌症报告数量有限的问题，并提示了原住民人群癌症发病率的总体模式。此外，这些结果可能有助于为未来涉及发病率升高的特定癌症部位的研究指明方向。
