宫内生长受限：高血压和肾脏疾病的胎儿编程
Intrauterine growth restriction: fetal programming of hypertension and kidney disease.
作者信息
Ojeda Norma B, Grigore Daniela, Alexander Barbara T
机构信息
Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
出版信息
Adv Chronic Kidney Dis. 2008 Apr;15(2):101-6. doi: 10.1053/j.ackd.2008.01.001.
Abstract
The etiology of hypertension historically includes 2 components: genetics and lifestyle. However, recent epidemiologic studies report an inverse relationship between birth weight and hypertension suggesting that a suboptimal fetal environment may also contribute to increased disease in later life. Experimental studies support this observation and indicate that cardiovascular/kidney disease originates in response to fetal adaptations to adverse conditions during prenatal life.
摘要
从历史角度来看，高血压的病因包括两个方面：遗传和生活方式。然而，最近的流行病学研究报告称出生体重与高血压之间存在负相关关系，这表明胎儿期环境欠佳也可能导致日后疾病风险增加。实验研究支持这一观察结果，并表明心血管/肾脏疾病源于胎儿在产前生活中对不利条件的适应性反应。
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