Wardlaw J M, Sellar R J, Abernethy L J
Department of Neuroradiology, Western General Hospital, Edinburgh, Scotland.
Neuroradiology. 1991;33(4):316-9. doi: 10.1007/BF00587814.
Caudate nucleus atrophy occurs in Huntington's disease and methods of measuring this have been described using axial CT, but these are indirect and lack sensitivity. We measured caudate nucleus area (blind to the subjects' clinical state) in 30 subjects with or at risk of Huntington's disease, and in 100 normal age matched controls. Fifteen subjects with established symptomatic Huntington's disease, 3 with early symptoms, and 3 presymptomatic subjects (2 showing a high probability for the Huntington's disease gene on genetic testing, and one who has since developed symptoms) were correctly identified. Three normal (gene negative) family members were also correctly identified. Outcome is awaited in 6. CT caudate area measurement is simple and reproducible and we have found it to be a useful confirmatory test for Huntington's disease.
尾状核萎缩见于亨廷顿舞蹈病，此前已有使用轴向CT测量尾状核萎缩的方法描述，但这些方法是间接的且缺乏敏感性。我们对30例患有或有患亨廷顿舞蹈病风险的受试者以及100例年龄匹配的正常对照者测量了尾状核面积（测量时对受试者的临床状态不知情）。15例确诊有症状的亨廷顿舞蹈病患者、3例有早期症状的患者以及3例症状前受试者（2例基因检测显示亨廷顿舞蹈病基因携带可能性高，1例后来出现症状）均被正确识别。3例正常（基因阴性）家庭成员也被正确识别。6例受试者的结果有待观察。CT尾状核面积测量简单且可重复，我们发现它是一种用于确诊亨廷顿舞蹈病的有用检测方法。
