Jing Hongkui, Pivik R T, Gilchrist Janet M, Badger Thomas M
Arkansas Children's Nutrition Center (ACNC), Little Rock, Arkansas 72202, USA.
Matern Child Nutr. 2008 Apr;4(2):136-45. doi: 10.1111/j.1740-8709.2007.00102.x.
Increasing concern has been recently raised on the possible effects of soy-derived phyto-oestrogens on the development of cognitive functions in infants. However, limited studies have been conducted to date, and no data have been made available for determining whether infant soy formula can affect normal development of the human brain. We compared electroencephalographic (EEG) spectral power derived from high-density recordings of infants fed milk-based or soy formula (46 fed milk-based formula and 39 fed soy formula) at 3 and 6 months of age. The spectral parameters included absolute power, relative power and spectral edge frequency (SEF) at 85%, 90% and 95% levels. The frequency domain contained four bands (0.1-3, 3-6, 6-9 and 9-12 Hz). EEG signals were collected from eight brain areas in each hemisphere. The results showed that the highest spectral power was mainly distributed in the low-frequency bands and was predominant in the frontal and anterior temporal areas. None of the spectral variables significantly differed between the soy- and milk-fed infants (anova, all P > 0.2). However, significant effects were indicated on the SEFs for factors of sex, age and brain area (all P < 0.01). Hemispheric differences in the absolute and relative power were also indicated. Our results suggest that the EEG power spectral development of soy-fed infants does not differ from that of infants fed milk-based formula. In addition, EEG spectral development appears more advanced in female than in male infants at 6 months.
近期，人们越来越关注大豆衍生的植物雌激素对婴儿认知功能发育可能产生的影响。然而，迄今为止所开展的研究有限，尚无数据可用于确定婴儿大豆配方奶粉是否会影响人类大脑的正常发育。我们比较了以牛奶为基础的配方奶粉或大豆配方奶粉喂养的婴儿（46名喂养以牛奶为基础的配方奶粉，39名喂养大豆配方奶粉）在3个月和6个月大时高密度脑电图（EEG）记录得出的频谱功率。频谱参数包括85%、90%和95%水平下的绝对功率、相对功率和频谱边缘频率（SEF）。频域包含四个频段（0.1 - 3、3 - 6、6 - 9和9 - 12赫兹）。从每个半球的八个脑区收集EEG信号。结果表明，最高频谱功率主要分布在低频段，且在额叶和颞前区占主导。大豆喂养和牛奶喂养的婴儿之间，所有频谱变量均无显著差异（方差分析，所有P>0.2）。然而，性别、年龄和脑区因素对SEF有显著影响（所有P<0.01）。还显示出绝对功率和相对功率的半球差异。我们的结果表明，大豆喂养婴儿的EEG功率谱发育与以牛奶为基础的配方奶粉喂养的婴儿并无差异。此外，在6个月大时，女性婴儿的EEG频谱发育似乎比男性婴儿更超前。
