Katabarwa Moses, Lakwo Tom, Habumogisha Peace, Richards Frank, Eberhard Mark
The Carter Center, Atlanta, Georgia 30307, USA.
Am J Trop Med Hyg. 2008 Mar;78(3):400-1.
We conducted a nodule prevalence survey in four onchocerciasis sentinel communities in Moyo and two in Kanungu districts of Uganda. Seven (33.3%) out of 21 excised "onchocercomas" (nodules) in Moyo District and excised onchocercomas from four of six persons in Kanungu District turned out to be cysts of Taenia solium. We concluded that the prediction of nodule prevalence for noninvasive rapid epidemiologic assessment (REA) to target areas for mass chemotherapy with ivermectin in the African Program for Onchocerciasis Control (APOC) supported areas may have been influenced by other pathologies. T. solium infection may be the main cause of "onchocerciasis-associated epileptic seizures" in many onchocerciasis endemic communities that have been causally linked to onchocerciasis. Lastly, widespread neurocysticercosis may be a concern in mass treatment programs that provide praziquantel (for managing schistosomiasis) or albendazole (for managing intestinal worms or lymphatic filariasis) because these drugs may kill cerebral cysticerci, resulting in severe adverse events.
我们在乌干达莫约区的4个盘尾丝虫病哨点社区以及卡农古区的2个社区开展了结节患病率调查。莫约区21个切除的“盘尾丝虫瘤”（结节）中有7个（33.3%），卡农古区6人中4人切除的盘尾丝虫瘤结果显示为猪带绦虫囊肿。我们得出结论，在非洲盘尾丝虫病防治计划（APOC）支持地区，针对使用伊维菌素进行大规模化疗的目标地区进行非侵入性快速流行病学评估（REA）时，对结节患病率的预测可能受到了其他病理情况的影响。猪带绦虫感染可能是许多盘尾丝虫病流行社区中“盘尾丝虫病相关性癫痫发作”的主要原因，而这些癫痫发作此前一直被认为与盘尾丝虫病存在因果关系。最后，在提供吡喹酮（用于治疗血吸虫病）或阿苯达唑（用于治疗肠道蠕虫或淋巴丝虫病）的大规模治疗项目中，广泛存在的神经囊尾蚴病可能是一个问题，因为这些药物可能会杀死脑囊尾蚴，从而导致严重的不良事件。
