Nsadha Zachary, Thomas Lian F, Fèvre Eric M, Nasinyama George, Ojok Lonzy, Waiswa Charles
School of Veterinary Medicine and Animal Resources, Makerere University, Kampala, Uganda.
BMC Vet Res. 2014 Oct 5;10:239. doi: 10.1186/s12917-014-0239-y.
Taenia solium is a zoonotic helminth with the potential to cause life threatening epilepsy in people through the aberrant larval infection of the brain called Neurocysticercosis (NCC). The pig is the intermediate host for T. solium where the larval form, cysticercus cellulosae, normally develops after the pig eats eggs of the parasite. Humans are the definitive host where the adult tapeworm develops and are infected through the consumption of poorly cooked, infected meat. T. solium has been acknowledged by the World Health Organization (WHO), Food and Agriculture Organization (FAO) and UK Department for International Development (DFID) as being a neglected zoonotic disease, and was recently included in the WHO roadmap for control of neglected tropical diseases. This neglect encompasses a lack of epidemiological data and a lack of validated, effective control strategies being adopted. Understanding the epidemiology of this parasite in the intermediate host is the first step towards designing suitable intervention strategies for the improvement of public health. This study was undertaken to provide an accurate and up-to-date estimate for the prevalence of porcine cysticercosis in the Lake Kyoga basin.
Sera from 378 pigs were analysed with the HP10 Antigen Enzyme Linked Immunosorbant Assay (ELISA) and the prevalence was found to be 25.7% (95% confidence interval 21.0% to 30.0%). Previous sero- surveillance in this region, using the B158/B60 Ag Elisa had indicated a prevalence of 8.6% in 2005 indicating a dramatic increase in prevalence (J. Parasitol Res, Article ID 375493, 2009) within a 6 year period.
This increasing prevalence in the disease indicates to us that there is currently no effective control of this parasite and that in this region of Uganda at least; cysticercosis remains a neglected zoonotic disease.
猪带绦虫是一种人畜共患的蠕虫，可通过幼虫异常感染大脑导致神经囊尾蚴病（NCC），从而使人患上危及生命的癫痫。猪是猪带绦虫的中间宿主，猪吞食该寄生虫的虫卵后，幼虫形式的猪囊尾蚴通常会在猪体内发育。人类是终宿主，成虫绦虫在人体内发育，人类通过食用未煮熟的受感染肉类而被感染。世界卫生组织（WHO）、联合国粮食及农业组织（FAO）和英国国际发展部（DFID）已承认猪带绦虫是一种被忽视的人畜共患疾病，并且最近被纳入了WHO控制被忽视热带病的路线图。这种忽视包括缺乏流行病学数据以及未采用经过验证的有效控制策略。了解该寄生虫在中间宿主中的流行病学情况是设计合适的干预策略以改善公共卫生的第一步。本研究旨在准确、最新地估计基奥加湖流域猪囊尾蚴病的流行率。
采用HP10抗原酶联免疫吸附测定（ELISA）对378头猪的血清进行分析，发现流行率为25.7%（95%置信区间为21.0%至30.0%）。该地区此前使用B158/B60 Ag ELISA进行的血清监测表明，2005年的流行率为8.6%，这表明在6年时间内流行率急剧上升（《寄生虫学研究杂志》，文章编号3第375493号，2009年）。
该疾病流行率的上升向我们表明，目前对这种寄生虫没有有效的控制措施，至少在乌干达的这个地区；囊尾蚴病仍然是一种被忽视的人畜共患疾病。
