偕二溴甲基芳烃：一种在克诺文纳格尔-多布纳反应中用于合成α,β-不饱和羧酸的非商业醛的便捷替代物。
gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acids.
作者信息
Augustine John Kallikat, Naik Yanjerappa Arthoba, Mandal Ashis Baran, Chowdappa Nagaraja, Praveen Vinuthan B
机构信息
Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India.
出版信息
J Org Chem. 2007 Dec 7;72(25):9854-6. doi: 10.1021/jo701888m. Epub 2007 Nov 14.
PMID:17999533
Abstract
A facile synthesis of alpha,beta-unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids.
摘要
描述了一种从偕二溴甲基芳烃简便合成α,β-不饱和羧酸的方法。偕二溴甲基芳烃首次在Knoevenagel-Doebner反应中用作醛的等效物，用于高效合成α,β-不饱和羧酸。
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