偕二溴甲基芳烃：一种在克诺文纳格尔-多布纳反应中用于合成α,β-不饱和羧酸的非商业醛的便捷替代物。

gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acids.

作者信息

Augustine John Kallikat, Naik Yanjerappa Arthoba, Mandal Ashis Baran, Chowdappa Nagaraja, Praveen Vinuthan B

机构信息

Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India.

出版信息

J Org Chem. 2007 Dec 7;72(25):9854-6. doi: 10.1021/jo701888m. Epub 2007 Nov 14.

DOI:10.1021/jo701888m

PMID:17999533

Abstract

A facile synthesis of alpha,beta-unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids.

摘要

描述了一种从偕二溴甲基芳烃简便合成α,β-不饱和羧酸的方法。偕二溴甲基芳烃首次在Knoevenagel-Doebner反应中用作醛的等效物，用于高效合成α,β-不饱和羧酸。