Kaddar Nisrin, Harthé Catherine, Déchaud Henri, Mappus Elizabeth, Pugeat Michel
INSERM U863, Lyon, France.
J Toxicol Environ Health A. 2008;71(8):471-3. doi: 10.1080/15287390801906824.
Bisphenol A (BPA) is an endocrine disruptor with weak estrogenic activity, used in epoxy resin and polycarbonate plastic. Human exposure may occur by contamination from food or food-contact material and by occupational scenarios. Occupational health hazards may be associated with allergic contact dermatitis (ACD) secondary to BPA exposure. Most ACD occurs in workers handling BPA products, such as plastic-product workers, and those exposed to epoxy adhesive tapes, foams, and dental products. The present study examined in vitro cutaneous penetration of BPA through pig skin, using a Franz cell. After 2, 5, and 10 h of exposure, total BPA skin content was 3, 6.9, and 11.4% of the applied dose, respectively. BPA remained essentially on the skin surface and penetration mainly accumulated in the dermis. As the pig skin model is a reliable predictor of percutaneous penetration in humans, these findings may be reassuring for workers in contact with BPA-based products.
双酚A（BPA）是一种具有弱雌激素活性的内分泌干扰物，用于环氧树脂和聚碳酸酯塑料。人体暴露可能通过食物或食品接触材料的污染以及职业场景发生。职业健康危害可能与双酚A暴露继发的过敏性接触性皮炎（ACD）有关。大多数ACD发生在处理双酚A产品的工人中，如塑料制品工人，以及接触环氧胶带、泡沫和牙科产品的工人。本研究使用Franz扩散池研究了双酚A在猪皮中的体外皮肤渗透情况。暴露2、5和10小时后，双酚A在皮肤中的总含量分别为给药剂量的3%、6.9%和11.4%。双酚A基本上留在皮肤表面，渗透主要积聚在真皮中。由于猪皮模型是人体经皮渗透的可靠预测指标，这些发现可能会让接触双酚A基产品的工人放心。
