Cerutti C, Gustin M P, Paultre C Z, Lo M, Julien C, Vincent M, Sassard J
Department of Physiology and Clinical Pharmacology, Faculty of Pharmacy, Centre National de la Recherche Scientifique, Unité de Recherche Associée 606, Lyon, France.
Am J Physiol. 1991 Oct;261(4 Pt 2):H1292-9. doi: 10.1152/ajpheart.1991.261.4.H1292.
Mechanisms underlying systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) beat-to-beat variability were investigated using spectral analysis in conscious genetically normotensive (LN) and hypertensive (LH) adult rats from the Lyon strains. In LN rats, basal SBP, DBP, and HR spectra exhibited peaks in low (LF: 0.38-0.45 Hz) and high (HF: 1.04-1.13 Hz) frequencies. The LF peak of SBP, and even more of DBP, could be attributed to the influence of the sympathetic nervous system as it disappeared after destruction of the sympathetic nerves or a combined alpha- and beta-adrenoceptor blockade, whereas it was higher after blockade of the parasympathetic system. The HF peak of HR, linked to the respiratory rate, was abolished by the parasympathetic system blockade, whereas those of SBP and DBP were enhanced. In LH rats, which exhibit a lower sympathetic activity, the LF peaks of SBP and DBP were less distinct compared with LN controls. We conclude that the LF peak of DBP and the HF peak of HR are likely to represent useful estimates of the sympathetic vascular control and of the parasympathetic cardiac control, respectively.
利用频谱分析，对来自里昂品系的清醒成年遗传性正常血压（LN）大鼠和高血压（LH）大鼠的收缩压（SBP）、舒张压（DBP）及心率（HR）逐搏变异性的潜在机制进行了研究。在LN大鼠中，基础SBP、DBP和HR频谱在低频（LF：0.38 - 0.45 Hz）和高频（HF：1.04 - 1.13 Hz）处均有峰值。SBP的LF峰值，甚至更多的DBP的LF峰值，可归因于交感神经系统的影响，因为在交感神经被破坏或α和β肾上腺素能受体联合阻断后其消失，而在副交感神经系统被阻断后则更高。与呼吸频率相关的HR的HF峰值在副交感神经系统被阻断后消失，而SBP和DBP的HF峰值则增强。在交感活性较低的LH大鼠中，与LN对照组相比，SBP和DBP的LF峰值不那么明显。我们得出结论，DBP的LF峰值和HR的HF峰值可能分别代表交感神经对血管的控制和副交感神经对心脏的控制的有效指标。
