Department of Surgical and Oncological Disciplines, Section of Oral Medicine V. Margiotta, University of Palermo, Palermo, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):e25-34. doi: 10.1016/j.oooo.2012.02.016. Epub 2012 Jul 6.
Modern pharmaceutical science has provided us with a wide range of substances to be administered with a wide large variety of dosage forms. Local drug delivery systems have been used for a long time; in particular, for the local therapy of diseases affecting the oral cavity. Although these diseases are often extremely responsive to local therapy, the mouth often presents various difficulties in the application of topical compounds (owing to saliva and the mouth's different functions), resulting in a short retention time of dosage forms with a consequent low therapeutic efficacy. To resolve these limitations, research today concentrates on the development of bioadhesive formulations. This review focuses on the permeability features of oral mucosa, the rationale of oral local drug delivery, and new potential bioadhesive local delivery systems. Furthermore, the most promising mucoadhesive systems proposed to locally treat oral diseases are discussed.
现代制药科学为我们提供了广泛的物质，可以用各种不同的剂型进行给药。局部药物递送系统已经使用了很长时间；特别是，用于治疗口腔疾病的局部治疗。尽管这些疾病通常对局部治疗反应非常敏感，但口腔在应用局部化合物时经常会出现各种困难（由于唾液和口腔的不同功能），导致剂型的保留时间短，从而导致治疗效果不佳。为了解决这些局限性，目前的研究集中在生物粘附制剂的开发上。本综述重点介绍口腔黏膜的渗透性特征、口腔局部药物递送的原理以及新的潜在生物粘附局部递送系统。此外，还讨论了用于局部治疗口腔疾病的最有前途的粘膜粘附系统。
