Dillon K A, Gross-Isseroff R, Israeli M, Biegon A
Department of Psychiatry, NYU Medical Center.
Brain Res. 1991 Jul 19;554(1-2):56-64. doi: 10.1016/0006-8993(91)90171-q.
Quantitative autoradiographic analysis of serotonin 5-HT1A receptors in the human brain, using [3H]8-OH-DPAT as a ligand, reveals region-specific decreases in receptor labeling with age in several cortical and hippocampal regions and in the raphe nuclei. This is due to a change in receptor density (Bmax) with no apparent change in affinity (Kd) as affirmed by saturation binding analysis on representative cortical regions. The presence of alcohol is associated with decreased binding in several cortical gyri. Suicide, gender and postmortem delay had no effect on 8-OH-DPAT binding.
使用[3H]8-OH-DPAT作为配体对人类大脑中的5-羟色胺5-HT1A受体进行定量放射自显影分析，结果显示，随着年龄增长，几个皮质和海马区域以及中缝核中的受体标记出现区域特异性减少。这是由于受体密度（Bmax）发生变化，而亲和力（Kd）没有明显变化，这一点已通过对代表性皮质区域的饱和结合分析得到证实。酒精的存在与几个脑回中的结合减少有关。自杀、性别和死后延迟对8-OH-DPAT结合没有影响。
