Trisolini Rocco, Cancellieri Alessandra, Paioli Daniela, Burzi Marcellino, Orlandi Paolo, Patelli Marco
Thoracic Endoscopy and Pulmonology Unit, Maggiore Hospital, Bologna, Italy.
Intern Med. 2008;47(6):537-42. doi: 10.2169/internalmedicine.47.0675. Epub 2008 Mar 17.
It has long been suggested that infectious agents may trigger sarcoidosis through their infectious or antigenic properties. A patient with airway colonization from P. aeruginosa in the setting of idiopathic bronchiolitis (IB) mimicking diffuse panbronchiolitis (DPB) developed sarcoidosis. Impressive clinical and radiological improvement of both bronchiolitis and sarcoidosis features was achieved with a one-year treatment with low-dose erythromycin, thus suggesting a possible link between the two conditions in this specific case. Pathogenic hypotheses and therapeutic implications are specifically discussed.
长期以来，人们一直认为感染因子可能通过其感染性或抗原性引发结节病。一名患有特发性细支气管炎（IB）并伴有铜绿假单胞菌气道定植的患者，其临床表现类似弥漫性泛细支气管炎（DPB），随后发展为结节病。低剂量红霉素治疗一年后，细支气管炎和结节病的临床及影像学特征均有显著改善，这表明在该特定病例中这两种疾病之间可能存在联系。文中特别讨论了致病假说及治疗意义。
