Heimann H, Stappler T, Wong D
St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
Eye (Lond). 2008 Oct;22(10):1342-59. doi: 10.1038/eye.2008.61. Epub 2008 Mar 14.
Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice.
Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000).
The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole.
The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.
比重比水大的眼内填充剂相较于传统填充剂具有若干理论优势，尤其是在治疗复杂视网膜脱离和眼底周边下部的增殖性玻璃体视网膜病变方面。然而，各种重填充剂的初始临床系列报道显示并发症发生率较高。因此，重填充剂尚未得到广泛应用。最近研发的三种重硅油填充剂，即Oxane HD、Densiron 68和HWS 46 - 3000，耐受性要好得多，目前似乎已进入常规临床实践。
对21篇关于9种不同重填充剂（氟硅油、C10F18、F6H8、OL62HV、Oxane HD、O62、F6H8 - 硅油混合物、Densiron 68和HWS 46 - 3000）临床应用的文献进行综述。
第一代（氟化硅油和全氟碳液体）和第二代（部分氟化烷烃）重填充剂的并发症发生率相对较高，例如填充剂乳化、眼内炎症和眼压升高。新一代重硅油（Oxane HD、Densiron 68和HWS 46 - 3000）的并发症谱似乎与传统硅油填充剂相当，同时能为下部视网膜和后极部提供更好的支撑。
最近研发的重硅油填充剂是治疗眼底下部复杂视网膜脱离的安全有效的工具。
