Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Anant Bajaj Retina Institute, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Standard Chartered-LVPEI Academy for Eye Care Education, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2024 Aug 1;72(8):1102-1111. doi: 10.4103/IJO.IJO_2417_23. Epub 2024 Jul 29.
Vitreous substitutes and tamponades occupy the vitreous cavity following vitrectomy in the management of various conditions such as retinal detachment, macular hole, and diabetic retinopathy. Such replacements can be for the short term (gases such as sulfur hexafluoride (SF6) and perfluoropropane (C3F8) or long term (such as silicone oils). Certain substitutes such as perfluorocarbon liquids are used only transiently during surgery as "a third hand" or rarely till a few days post surgery. Hydrogels and hyaluronan derivatives are among the newer vitreous substitutes that are showing promise for the future, albeit still under investigation. still being investigated for use as vitreous substitutes. These materials have properties similar to the natural vitreous and may offer advantages such as improved biocompatibility and biodegradability. Although vitreous substitutes are valuable tools in treating vitreoretinal conditions, they carry risks and potential complications such as cataract formation, glaucoma, and inflammation. The current communication extensively reviews the available literature on vitreous tamponades. It details the composition and properties of various vitreous substitutes and tamponades available for the clinician, highlighting the techniques of usage, indications, and limitations.
玻璃体替代物和填充物在玻璃体切割术后用于各种疾病的治疗，如视网膜脱离、黄斑裂孔和糖尿病性视网膜病变。这些替代物可以是短期的（如六氟化硫 (SF6) 和全氟丙烷 (C3F8) 等气体），也可以是长期的（如硅油）。某些替代物，如全氟碳液体，仅在手术期间作为“第三只手”短暂使用，或在手术后几天内使用。水凝胶和透明质酸衍生物是新型玻璃体替代物中的一部分，它们具有广阔的应用前景，尽管仍在研究中。仍在研究中，作为玻璃体替代物。这些材料具有类似于天然玻璃体的特性，可能具有改善的生物相容性和生物降解性等优点。尽管玻璃体替代物是治疗玻璃体视网膜疾病的有价值的工具，但它们也存在风险和潜在并发症，如白内障形成、青光眼和炎症。本通讯广泛回顾了有关玻璃体填充物的现有文献。它详细介绍了各种可用于临床医生的玻璃体替代物和填充物的组成和特性，强调了使用技术、适应证和局限性。
