Division of Gastrointestinal and Minimally Invasive Surgery, Carolinas Medical Center, Charlotte, NC 28203, USA.
HPB (Oxford). 2007;9(5):363-7. doi: 10.1080/13651820701611218.
We evaluated two new radiofrequency devices in an in vivo porcine model.
Multiprobe radiofrequency ablation (RFA) was used in a porcine model with an impedance-based algorithm in one experiment and clustered probes with and without switcher controllers in another; a Pringle maneuver was used with half of the ablations.
The impedance experiment included 13 ablations, with a mean length of 7.0 cm and width of 2.9 cm (95% CI) and an average time of 596 s. Ablation volumes were significantly larger (54.1+/-11.7 cc(3) vs 34.9+/-4.8 cc(3), p<0.05) and ablation times were significantly shorter (359 s vs 834 s, p<0.05) for the Pringle group compared with the No Pringle group, respectively. The switcher controller experiment included 34 RFAs. Diameter (mm) (51.4 vs 40.3, p<0.0001), surface area (cm(2)) (22.4 vs 16.0, p<0.0002), and volume (cc) (66.1 vs 36.9, p<0.0001) were significantly larger for the combination probes with switcher controller compared with clustered probes, respectively. Ablation volumes for the Pringle vs No Pringle groups in the combination probes were 68.0 cc vs 64.3 cc and for the clustered probes 40.1 cc vs. 33.7 cc, respectively.
Multiprobe ablations using RFA are promising technologies that need further study to evaluate their clinical utility.
我们在活体猪模型中评估了两种新型射频设备。
在一项实验中，采用基于阻抗的算法对多探针射频消融（RFA）进行了研究，而在另一项实验中则使用了带有和不带开关控制器的簇状探针；半数消融采用了普莱勒手法。
阻抗实验包括 13 次消融，平均长度为 7.0cm，宽度为 2.9cm（95%CI），平均时间为 596s。与无普莱勒手法组相比，普莱勒手法组的消融体积明显更大（54.1+/-11.7cc(3) vs 34.9+/-4.8cc(3)，p<0.05），消融时间明显更短（359s vs 834s，p<0.05）。开关控制器实验包括 34 次 RFA。与簇状探针相比，组合探针的直径（mm）（51.4 vs 40.3，p<0.0001）、表面积（cm(2)）（22.4 vs 16.0，p<0.0002）和体积（cc）（66.1 vs 36.9，p<0.0001）均显著增大。普莱勒手法组和无普莱勒手法组在组合探针中的消融体积分别为 68.0cc vs 64.3cc和 40.1cc vs 33.7cc，而在簇状探针中则分别为 68.0cc vs 64.3cc和 40.1cc vs 33.7cc。
多探针 RFA 消融技术具有广阔的应用前景，需要进一步研究以评估其临床应用价值。
