Vasques Ana Carolina J, Rosado Lina Enriqueta F P L, Cássia GAlfenas Rita de, Geloneze Bruno
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, MG, Brazil.
Arq Bras Endocrinol Metabol. 2008 Feb;52(1):32-9. doi: 10.1590/s0004-27302008000100006.
Beta-cell dysfunction and insulin resistance are interrelated metabolic abnormalities in the aetiology of Type 2 Diabetes. In several countries, increases in the prevalence of obesity and diabetes have been observed in association with the presence of insulin resistance. In this context, measurement of insulin resistance and beta-cell function is useful. The HOMA indexes (Homeostasis Model Assessment) have been widely used, representing an alternative for the evaluation of these parameters, particularly as a fast, easy and cheap method. This review discusses the origin and evolution of the HOMA index, as well as details of the method, analyzing features related to its validation and the cutoff limits for its interpretation.
β细胞功能障碍和胰岛素抵抗是2型糖尿病病因中相互关联的代谢异常。在一些国家，肥胖症和糖尿病患病率的上升与胰岛素抵抗的存在有关。在这种情况下，测量胰岛素抵抗和β细胞功能是有用的。HOMA指数（稳态模型评估）已被广泛使用，是评估这些参数的一种替代方法，特别是作为一种快速、简便且廉价的方法。本文综述讨论了HOMA指数的起源和演变，以及该方法的细节，分析了与其验证相关的特征及其解释的临界值。
