Zhao Yong, Pu Jian-Xin, Huang Sheng-Xiong, Wu Ying-Li, Yang Li-Bin, Xiao Wei-Lie, Han Quan-Bin, Chen Guo-Qiang, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
J Nat Prod. 2009 Jan;72(1):125-9. doi: 10.1021/np800484j.
Nine new ent-kaurane diterpenoids, isoscoparins D-L (1-9), and an artificial product, the acetonide of rabdoloxin A (10), along with 16 known analogues (11-26), were isolated from the leaves of Isodon scoparius. The new structures were determined by 1D and 2D NMR spectroscopic analysis. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.
从香茶菜（Isodon scoparius）叶中分离得到9个新的对映-贝壳杉烷二萜类化合物，异斯柯帕苷D-L（1-9），以及1个人工产物，兔耳草醛A的丙酮化物（10），还有16个已知类似物（11-26）。通过一维和二维核磁共振光谱分析确定了新化合物的结构。对部分化合物针对NB4、A549、PC-3、MCF-7和SH-SY5Y细胞系的细胞毒性进行了评估。
