庐山香茶菜的细胞毒性成分。

Cytotoxic constituents of Isodon rubescens var. lushiensis.

作者信息

Han Quan-Bin, Zhao Ai-Hua, Zhang Ji-Xia, Lu Yang, Zhang Li-Li, Zheng Qi-Tai, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2003 Oct;66(10):1391-4. doi: 10.1021/np030165w.

DOI:10.1021/np030165w

PMID:14575445

Abstract

Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

摘要

从庐山香茶菜（Isodon rubescens var. lushiensis）的叶子中分离出了5个新的对映-贝壳杉烷二萜类化合物，庐山香茶素F-J（1-5），以及10个已知化合物，桂东香茶素A-C（6-8）、狭叶香茶菜素（9）、6-表狭叶香茶菜素（10）、刻叶紫堇明碱J（11）、栀子苷元D、5,3',4'-三羟基-6,7,8-三甲氧基黄酮、pedalitin和槲皮素。通过光谱分析以及化合物1的X射线晶体学分析确定了化合物1-5的结构。对化合物1-11针对K562白血病细胞的细胞毒性作用进行了评估。