Gabellieri Cristina, Reynolds Steven, Lavie Arnon, Payne Geoffrey S, Leach Martin O, Eykyn Thomas R
Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Downs Road Sutton, Surrey, SM2 5PT, United Kingdom.
J Am Chem Soc. 2008 Apr 9;130(14):4598-9. doi: 10.1021/ja8001293. Epub 2008 Mar 18.
Choline is a precursor of cellular phospholipid metabolism that provides Magnetic Resonance (MR) and Positron Emission Tomography (PET) biomarkers for cancer detection and response assessment. Employing Dynamic Nuclear Polarization we show that the MR signal of 15N in choline can be enhanced by at least 4 orders of magnitude with a relaxation time of ca. 4 min, providing a method to observe the action of choline kinase, an important target for novel cancer therapeutics.
胆碱是细胞磷脂代谢的前体，可为癌症检测和反应评估提供磁共振（MR）和正电子发射断层扫描（PET）生物标志物。利用动态核极化技术，我们发现胆碱中15N的MR信号可增强至少4个数量级，弛豫时间约为4分钟，这为观察胆碱激酶的作用提供了一种方法，胆碱激酶是新型癌症治疗的重要靶点。
