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用于磁共振波谱和成像的超极化氮标记分子成像探针的最新进展。

State-of-the-art accounts of hyperpolarized N-labeled molecular imaging probes for magnetic resonance spectroscopy and imaging.

作者信息

Park Hyejin, Wang Qiu

机构信息

Department of Chemistry, Duke University Durham NC 27708 USA

出版信息

Chem Sci. 2022 May 17;13(25):7378-7391. doi: 10.1039/d2sc01264b. eCollection 2022 Jun 29.

DOI:10.1039/d2sc01264b
PMID:35872812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9241963/
Abstract

Hyperpolarized isotope-labeled agents have significantly advanced nuclear magnetic resonance spectroscopy and imaging (MRS/MRI) of physicochemical activities at molecular levels. An emerging advance in this area is exciting developments of N-labeled hyperpolarized MR agents to enable acquisition of highly valuable information that was previously inaccessible and expand the applications of MRS/MRI beyond commonly studied C nuclei. This review will present recent developments of these hyperpolarized N-labeled molecular imaging probes, ranging from endogenous and drug molecules, and chemical sensors, to various N-tagged biomolecules. Through these examples, this review will provide insights into the target selection and probe design rationale and inherent challenges of HP imaging in hopes of facilitating future developments of N-based biomedical imaging agents and their applications.

摘要

超极化同位素标记试剂显著推动了分子水平物理化学活性的核磁共振波谱学和成像技术（MRS/MRI）的发展。该领域的一个新进展是令人兴奋的N标记超极化磁共振试剂的开发，它能够获取以前无法获得的高价值信息，并将MRS/MRI的应用扩展到除常用的C核之外的领域。本综述将介绍这些超极化N标记分子成像探针的最新进展，范围从内源性和药物分子、化学传感器到各种N标记的生物分子。通过这些实例，本综述将深入探讨靶点选择、探针设计原理以及超极化成像的内在挑战，以期推动基于N的生物医学成像试剂及其应用的未来发展。

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