Stadler B M, Gang Q, Vogel M, Jarolim E, Miescher S, Aebischer I, de Weck A L
Institute of Clinical Immunology, University of Berne, Inselspital, Switzerland.
Int Arch Allergy Appl Immunol. 1991;94(1-4):83-6. doi: 10.1159/000235332.
Human sera contain anti-IgE autoantibodies with diverse biological functions in vitro. Opposite functions can be shown for triggering of IgE-mediated histamine release from human basophils in terms of anaphylactogenic or nonanaphylactogenic autoantibodies. Furthermore, autoantibodies are either capable of removing IgE from the surface of CD23-positive cells of binding more IgE to such cells. A similar dichotomy seems also to exist for the effect of autoantibodies on human IgE mRNA synthesis as well as IL-4-induced proliferation of human mononuclear cells. Thus, anti-IgE autoantibodies may represent a key factor in the manifestation and the development of allergic disease.
