Flores I, Mariano T M, Pestka S
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635.
J Biol Chem. 1991 Oct 25;266(30):19875-7.
It was proposed that human interferon omega (omega) binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. However, since no studies were performed to provide direct evidence for this hypothesis, we carried out cross-linking experiments and saturation binding assays between a 32P-labeled human interferon-alpha (Hu-IFN-alpha) and unlabeled Hu-IFN-alpha A, -beta, -gamma, and -omega. These assays demonstrated that Hu-IFN-alpha A, -beta, and -omega, but not Hu-IFN-gamma, were able to block binding of 32P-labeled Hu-IFN-alpha A to human cells. These results indicate that Hu-IFN-omega binds to the alpha/beta receptor.
有人提出人ω干扰素（ω）与α/β干扰素受体结合，但不与γ干扰素受体结合。然而，由于没有进行研究来为这一假设提供直接证据，我们进行了32P标记的人α干扰素（Hu-IFN-α）与未标记的Hu-IFN-α A、-β、-γ和-ω之间的交联实验和饱和结合试验。这些试验表明，Hu-IFN-α A、-β和-ω，而不是Hu-IFN-γ，能够阻断32P标记的Hu-IFN-α A与人类细胞的结合。这些结果表明Hu-IFN-ω与α/β受体结合。
