青少年胼胝体的微观结构完整性与神经心理表现相关。
Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.
作者信息
Fryer Susanna L, Frank Lawrence R, Spadoni Andrea D, Theilmann Rebecca J, Nagel Bonnie J, Schweinsburg Alecia D, Tapert Susan F
机构信息
San Diego State University/University of California-San Diego, Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, San Diego, CA 92120, USA.
出版信息
Brain Cogn. 2008 Jul;67(2):225-33. doi: 10.1016/j.bandc.2008.01.009. Epub 2008 Mar 17.
Abstract
BACKGROUND
Diffusion tensor imaging (DTI) has revealed microstructural aspects of adolescent brain development, the cognitive correlates of which remain relatively uncharacterized.
METHODS
DTI was used to assess white matter microstructure in 18 typically developing adolescents (ages 16-18). Fractional anisotropy (FA) and mean diffusion (MD) were evaluated within the splenium and body of the corpus callosum in relation to cognitive performance.
RESULTS
Visuospatial construction abilities were associated with white matter integrity in both the splenium and body of the corpus callosum, while only splenium integrity was associated with language and psychomotor function.
CONCLUSION
Results suggest that, for typically developing adolescents, white matter coherence positively relates to visuospatial, psychomotor, and language skills. These findings may have implications for the cognitive functioning of clinical populations in which typical white matter development is altered.
摘要
背景
扩散张量成像（DTI）揭示了青少年大脑发育的微观结构方面，但其认知相关性仍相对未得到充分描述。
方法
使用DTI评估18名发育正常的青少年（年龄16 - 18岁）的白质微观结构。在胼胝体压部和体部评估各向异性分数（FA）和平均扩散率（MD）与认知表现的关系。
结果
视觉空间构建能力与胼胝体压部和体部的白质完整性相关，而只有压部完整性与语言和精神运动功能相关。
结论
结果表明，对于发育正常的青少年，白质连贯性与视觉空间、精神运动和语言技能呈正相关。这些发现可能对典型白质发育发生改变的临床人群的认知功能具有启示意义。
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本文引用的文献
1
A power primer.强力底漆。
Psychol Bull. 1992 Jul;112(1):155-9. doi: 10.1037//0033-2909.112.1.155.
2
Depressive symptoms in adolescents: associations with white matter volume and marijuana use.青少年的抑郁症状：与白质体积及大麻使用的关联。
J Child Psychol Psychiatry. 2007 Jun;48(6):592-600. doi: 10.1111/j.1469-7610.2007.01728.x.
3
Diffusion tensor imaging: Application to the study of the developing brain.扩散张量成像：在发育中大脑研究中的应用。
J Am Acad Child Adolesc Psychiatry. 2007 Feb;46(2):213-23. doi: 10.1097/01.chi.0000246064.93200.e8.
4
Age-related changes in prefrontal white matter volume across adolescence.青春期前额叶白质体积的年龄相关变化。
Neuroreport. 2006 Sep 18;17(13):1427-31. doi: 10.1097/01.wnr.0000233099.97784.45.
5
The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition?胼胝体在半球间信息传递中的作用：兴奋还是抑制？
Neuropsychol Rev. 2005 Jun;15(2):59-71. doi: 10.1007/s11065-005-6252-y.
6
A model for diffusion in white matter in the brain.一种大脑白质中扩散的模型。
Biophys J. 2005 Nov;89(5):2927-38. doi: 10.1529/biophysj.105.063016. Epub 2005 Aug 12.
7
Evaluation of corpus callosum anisotropy in young adults with fetal alcohol syndrome according to diffusion tensor imaging.根据扩散张量成像评估胎儿酒精综合征青年成人的胼胝体各向异性
Alcohol Clin Exp Res. 2005 Jul;29(7):1214-22. doi: 10.1097/01.alc.0000171934.22755.6d.
8
Frontostriatal microstructure modulates efficient recruitment of cognitive control.额纹状体微观结构调节认知控制的有效招募。
Cereb Cortex. 2006 Apr;16(4):553-60. doi: 10.1093/cercor/bhj003. Epub 2005 Jul 20.
9
fMRI response to spatial working memory in adolescents with comorbid marijuana and alcohol use disorders.功能磁共振成像对同时患有大麻和酒精使用障碍的青少年空间工作记忆的反应。
Drug Alcohol Depend. 2005 Aug 1;79(2):201-10. doi: 10.1016/j.drugalcdep.2005.01.009. Epub 2005 Feb 26.
10
Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism.胼胝体的畸形与微观结构退化：年龄与酗酒的相互作用。
Neurobiol Aging. 2006 Jul;27(7):994-1009. doi: 10.1016/j.neurobiolaging.2005.05.007. Epub 2005 Jun 16.
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