Camlica Hakan, Duranyildiz Derya, Oguz Hilal, Oral Ethem Nezih, Yasasever Vildan
Preventive Oncology, Biostatistics and Epidemiology, Institute of Oncology, University of Istanbul, Capa, 34390 Istanbul, Turkey.
Pathol Oncol Res. 2008 Mar;14(1):79-83. doi: 10.1007/s12253-008-9002-7. Epub 2008 Mar 18.
The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum MIF, CEA, CA 19-9 levels and their various combinations in patients with gastric cancer. Study group consists of pathologically verified, gastric cancer (n = 63) and apparently healthy controls (n = 50). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Serum values of patients were significantly higher than the controls (p = 0.011). Diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their various combinations. The best results were achieved with the marker combination of MIF-CEA-CA 19-9 and MIF-CEA combination. In our opinion, the combination of the markers MIF-CEA is a valuable diagnostic tool for gastric cancer.
本研究旨在探讨血清巨噬细胞移动抑制因子（MIF）、癌胚抗原（CEA）、糖类抗原19-9（CA 19-9）水平及其不同组合对胃癌患者的敏感性、特异性、预测值和准确性。研究组包括经病理证实的胃癌患者（n = 63）和明显健康的对照组（n = 50）。采用酶联免疫吸附测定（ELISA）法测定血清MIF浓度。患者的血清值显著高于对照组（p = 0.011）。计算了每个标志物及其不同组合的诊断敏感性、特异性、预测值和准确性。MIF-CEA-CA 19-9标志物组合和MIF-CEA组合取得了最佳结果。我们认为，MIF-CEA标志物组合是一种有价值的胃癌诊断工具。
