来自滇桑茎皮的两种新型狄尔斯-阿尔德型加合物。

Two new Diels-Alder-type adducts from the stem barks of Morus yunanensis.

作者信息

Kang Jie, Cui Xi-Qiang, Wang Hong-Qing, Yu De-Quan, Chen Ruo-Yun

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.

出版信息

J Asian Nat Prod Res. 2014;16(6):617-22. doi: 10.1080/10286020.2014.923407. Epub 2014 Jun 26.

DOI:10.1080/10286020.2014.923407

PMID:24965853

Abstract

Two new Diels-Alder adducts, yunanensins B and D (1 and 2), were isolated from the stem bark of Morus yunanensis. Their structures were determined by spectroscopic analysis. Compounds 1 and 2 showed moderate antioxidant effects on liver microsomal lipid peroxidation induced by Fe(2+)-Cys system, with inhibitory ratios of 57.1% and 67.9% at a concentration of 10(-5) mol/l.

摘要

从滇桑茎皮中分离得到两个新的狄尔斯-阿尔德加成物，即滇桑素B和D（1和2）。通过光谱分析确定了它们的结构。化合物1和2对Fe(2+)-半胱氨酸体系诱导的肝微粒体脂质过氧化表现出中等程度的抗氧化作用，在浓度为10(-5) mol/l时抑制率分别为57.1%和67.9%。