Fatima Maryam, Dar Mudasir A, Dhanavade Maruti J, Abbas Syed Zaghum, Bukhari Mohd Nadeem, Arsalan Abdullah, Liao Yangzhen, Wan Jingqiong, Shah Syed Bukhari Jehangir, Ouyang Zhen
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
School of the Environment and Safety Engineering, Biofuel Institute, Jiangsu University, Zhenjiang 212013, China.
Biology (Basel). 2024 Jul 7;13(7):506. doi: 10.3390/biology13070506.
Traditional natural products have been the focus of research to explore their medicinal properties. One such medicinally important plant is the white mulberry, , widely distributed in the Asian subcontinent. It is one of the most cultivated species of mulberry tree and has attracted more focus from researchers because of its abundance in phytochemicals as well as multipurpose uses. The leaves, fruits and other parts of the white mulberry plant act as a source of valuable bioactive compounds like flavonoids, phenolic acids, terpenoids and alkaloids. These secondary metabolites have manifold healthy uses as they possess antioxidant, anti-inflammatory, antidiabetic, neutrotrophic, and anticancer properties. Despite the increasing scientific interest in this plant, there are very few reviews that highlight the phytochemistry and biological potential of white mulberry for biomedical research. To this end, this review elaborates the phytochemistry, biosynthetic pathways and pharmacological activities of the glycoside flavonoids of . A comprehensive analysis of the available literature indicates that could emerge as a promising natural agent to combat diverse conditions including diabetes, cancer, inflammation and infectious diseases. To achieve such important objectives, it is crucial to elucidate the biosynthesis and regulation mechanisms of the bioactive compounds in white mulberry as well as the multifaceted pharmacological effects attributed to this plant resource. The present review paper is intended to present a summary of existing scientific data and a guide for further research in the phytochemistry and pharmacology of white mulberry. Further, a biosynthetic pathway analysis of the glycoside flavonoid in mulberry is also given. Lastly, we discuss the pros and cons of the current research to ensure the prudent and effective therapeutic value of mulberry for promoting human and animal health.
传统天然产物一直是探索其药用特性的研究重点。一种具有重要药用价值的植物是白桑，广泛分布于亚洲次大陆。它是桑树中种植最为广泛的品种之一，因其富含植物化学物质以及具有多种用途而吸引了研究人员更多的关注。白桑植物的叶子、果实和其他部分是黄酮类化合物、酚酸、萜类化合物和生物碱等有价值的生物活性化合物的来源。这些次生代谢产物具有多种健康用途，因为它们具有抗氧化、抗炎、抗糖尿病、神经营养和抗癌特性。尽管科学界对这种植物的兴趣与日俱增，但很少有综述强调白桑在生物医学研究中的植物化学和生物潜力。为此，本综述阐述了白桑糖苷黄酮类化合物的植物化学、生物合成途径和药理活性。对现有文献的综合分析表明，白桑有望成为对抗包括糖尿病、癌症、炎症和传染病在内的多种疾病的天然药物。为实现这些重要目标，阐明白桑中生物活性化合物的生物合成和调控机制以及该植物资源的多方面药理作用至关重要。本综述旨在总结现有科学数据，并为白桑植物化学和药理学的进一步研究提供指导。此外，还对白桑中糖苷黄酮类化合物的生物合成途径进行了分析。最后，我们讨论了当前研究的利弊，以确保白桑在促进人类和动物健康方面具有审慎且有效的治疗价值。
