Lerbaek Anne, Kyvik Kirsten Ohm, Ravn Henrik, Menné Torkil, Agner Tove
National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Contact Dermatitis. 2008 Apr;58(4):210-6. doi: 10.1111/j.1600-0536.2007.01305.x.
Few population-based clinical follow-up studies on hand eczema are reported.
The aim of this study was to characterize clinical symptoms and to examine occupational and medical consequences as well as persistence of hand eczema in a population-based twin cohort.
PATIENTS/METHODS: A total of 274 individuals with and without hand eczema were examined, patch tested, and interviewed in 1997-1998 and 2005-2006. Data on 188 individuals with hand eczema in 2005-2006 were analysed.
Erythema and scaling were the most frequent symptoms, and fingers and palms were most often affected. Mean hand eczema severity index score in individuals with clinical symptoms was 12.0. Sick leave was reported by 12.4%; job change by 8.5%. Being in the lowest socio-economic group and atopic dermatitis were risk factors for sick leave [odds ratio (OR) = 5.6; 95% confidence interval (95% CI) 1.5-22.9 and OR = 2.9; 95% CI 1.0-8.1]. The majority (63.4%) had seen a doctor at least once, and atopic dermatitis was a risk factor for more than 1 visit (OR = 3.0; 95% CI 1.4-6.4). Duration of >10 years was a risk factor for persistence of symptoms, which was reported by 67.7%.
The clinical picture and consequences of hand eczema vary; however, the majority experience chronic symptoms.
基于人群的手部湿疹临床随访研究报道较少。
本研究旨在描述手部湿疹的临床症状，探讨其职业和医疗后果以及在基于人群的双胞胎队列中的持续情况。
患者/方法：1997 - 1998年和2005 - 2006年，共对274名有或无手部湿疹的个体进行了检查、斑贴试验和访谈。对2005 - 2006年188名手部湿疹患者的数据进行了分析。
红斑和脱屑是最常见的症状，手指和手掌最常受累。有临床症状个体的手部湿疹严重程度指数平均评分为12.0。报告病假的占12.4%；换工作的占8.5%。处于社会经济最低组和患有特应性皮炎是病假的危险因素[比值比（OR）= 5.6；95%置信区间（95%CI）1.5 - 22.9，OR = 2.9；95%CI 1.0 - 8.1]。大多数（63.4%）至少看过一次医生，特应性皮炎是就诊次数超过一次的危险因素（OR = 3.0；95%CI 1.4 - 6.4）。病程>10年是症状持续的危险因素，症状持续的占67.7%。
手部湿疹的临床表现和后果各不相同；然而，大多数人经历慢性症状。
