Lerbaek A, Kyvik K O, Ravn H, Menné T, Agner T
National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark.
Br J Dermatol. 2007 Sep;157(3):552-7. doi: 10.1111/j.1365-2133.2007.08088.x. Epub 2007 Jul 16.
Population-based studies on the incidence of hand eczema are sparse.
The aim of this prospective follow-up study was to determine the incidence rate of hand eczema in a population-based twin cohort. Secondly, the role of genetic factors and other potential risk factors for hand eczema was investigated.
A questionnaire on self-reported hand eczema was answered by 5610 and 4128 twin individuals in 1996 and 2005, respectively. Data were analysed in a Poisson regression analysis.
The crude incidence rate was 8.8 cases per 1000 person-years (95% confidence interval, [CI] 7.7-9.9). Incidence rate ratios (IRRs) dependent on the co-twin's hand eczema status revealed a significant, doubled risk for monozygotic twin individuals with a co-twin affected by hand eczema, compared with dizygotic twin individuals with a co-twin affected by hand eczema (IRR 2.4, 95% CI 1.4-4.1). Also, significantly increased IRRs were found for positive patch test, atopic dermatitis, and wet work.
Hand eczema is still a frequent disease and genetic factors are confirmed important risk factors. Positive patch test, atopic dermatitis and wet work were associated with an increased risk, whereas no association with age, sex, smoking or alcohol was found.
基于人群的手部湿疹发病率研究较少。
这项前瞻性随访研究的目的是确定基于人群的双胞胎队列中手部湿疹的发病率。其次，研究遗传因素和其他手部湿疹潜在风险因素的作用。
1996年和2005年分别有5610名和4128名双胞胎个体回答了关于自我报告手部湿疹的问卷。数据采用泊松回归分析进行分析。
粗发病率为每1000人年8.8例（95%置信区间，[CI]7.7 - 9.9）。取决于同卵双胞胎手部湿疹状况的发病率比（IRR）显示，与同卵双胞胎患手部湿疹时的异卵双胞胎个体相比，同卵双胞胎个体中其同卵双胞胎患手部湿疹时的风险显著增加一倍（IRR 2.4，95% CI 1.4 - 4.1）。此外，斑贴试验阳性、特应性皮炎和从事湿作业的发病率比也显著增加。
手部湿疹仍然是一种常见疾病，遗传因素被确认为重要的风险因素。斑贴试验阳性、特应性皮炎和从事湿作业与风险增加相关，而未发现与年龄、性别、吸烟或饮酒有关联。
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