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糖化蛋白与炎症蛋白及牙周病参数的相关性研究。

Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters.

机构信息

Altamash Institute of Dental Medicine, Department of Periodontology, Karachi, Pakistan.

Karolinska Institutet, Department of Dental Medicine, Division of Oral Diseases, Section of Periodontology, Huddinge, Sweden.

出版信息

J Diabetes Res. 2020 Jan 11;2020:6450742. doi: 10.1155/2020/6450742. eCollection 2020.

DOI:10.1155/2020/6450742
PMID:31998807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6977320/
Abstract

Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption.

摘要

牙周炎是一种慢性炎症性疾病，可能导致糖尿病的发生。本研究旨在探讨糖化蛋白的水平及其与牙周和全身炎症的相关性。51 名牙周炎患者和 20 名健康受试者接受了探诊袋深度（PPD）测量。PPD 总深度和 PPD 疾病深度（包括和不包括牙齿调整）被用作连续指标。下颌前磨牙和磨牙的边缘骨丧失（MBL）通过数字方式进行测量。还分析了体重指数（BMI）和腰围（WC）。所有受试者均测量了糖化血红蛋白（HbA1c）和果糖胺（FrAm）水平。使用多重邻近延伸分析（PEA）同时测量血清样本中的 92 种蛋白质。在 16 种蛋白质中，HbA1c 和 FrAm 与 IL-10、FGF-21、MCP-1 和 TNF beta 呈负相关。HbA1c 与 OPG 呈直接相关。HbA1c 与疾病严重程度的参数始终显著相关。糖尿病患者的调整后 PPD 总深度和缺牙数增加，而非糖尿病牙周炎患者的 RANKL 和 RANKL/OPG 比值最高。牙周炎患者的高血糖状态与抗炎蛋白水平降低以及骨吸收失调有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/a3e70b1ec571/JDR2020-6450742.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/41c3cfd8a818/JDR2020-6450742.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/04ae7dee6c12/JDR2020-6450742.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/88b0cb75884c/JDR2020-6450742.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/a3e70b1ec571/JDR2020-6450742.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/41c3cfd8a818/JDR2020-6450742.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/04ae7dee6c12/JDR2020-6450742.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/88b0cb75884c/JDR2020-6450742.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/587c/6977320/a3e70b1ec571/JDR2020-6450742.004.jpg

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Type 2 diabetes affects bone cells precursors and bone turnover.2型糖尿病会影响骨细胞前体和骨转换。
BMC Endocr Disord. 2018 Aug 8;18(1):55. doi: 10.1186/s12902-018-0283-x.
3
Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis.牙周病影响类风湿关节炎患者和非类风湿关节炎患者的破骨细胞生成骨标志物。
Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis.
基于人群的靶向蛋白质组学研究发现血清 PECAM-1 和 TRIM21 是牙周炎的炎症标志物。
Clin Oral Investig. 2023 Dec 29;28(1):59. doi: 10.1007/s00784-023-05442-z.
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