Hanley Jonathan G
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK.
Pharmacol Ther. 2008 Apr;118(1):152-60. doi: 10.1016/j.pharmthera.2008.02.002. Epub 2008 Feb 20.
AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein interacting with C-kinase) is a PDZ and BAR domain-containing protein that has recently emerged as a key regulator of AMPA receptor traffic. Via the PDZ domain, PICK1 interacts directly with AMPA receptor subunits and is involved in the regulated removal of AMPA receptors from the synaptic plasma membrane. PICK1 has the ability to functionally interact with a number of cellular processes, including calcium signaling, actin polymerisation and phospholipid membrane architecture. In this review, I summarize recent findings that describe the importance of PICK1 in neurons and its specific molecular characteristics that enable it to regulate AMPA receptor trafficking.
α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体转运是调节突触强度的基本机制，因此可能是学习和记忆相关细胞过程的基础。与C激酶相互作用的蛋白质1（PICK1）是一种含有PDZ和BAR结构域的蛋白质，最近已成为AMPA受体转运的关键调节因子。通过PDZ结构域，PICK1直接与AMPA受体亚基相互作用，并参与从突触质膜上有调节地移除AMPA受体。PICK1能够与许多细胞过程进行功能相互作用，包括钙信号传导、肌动蛋白聚合和磷脂膜结构。在这篇综述中，我总结了最近的研究发现，这些发现描述了PICK1在神经元中的重要性及其能够调节AMPA受体转运的特定分子特征。
