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Genotyping of Clostridium perfringens isolates collected from food poisoning outbreaks and healthy individuals in Japan based on the cpe locus.基于cpe基因座对从日本食物中毒暴发事件和健康个体中分离出的产气荚膜梭菌菌株进行基因分型。
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Humans as reservoir for enterotoxin gene--carrying Clostridium perfringens type A.作为携带肠毒素基因的A型产气荚膜梭菌储存宿主的人类。
Emerg Infect Dis. 2006 Nov;12(11):1724-9. doi: 10.3201/eid1211.060478.
3
Comparative analysis of prevalence, risk factors, and molecular epidemiology of antibiotic-associated diarrhea due to Clostridium difficile, Clostridium perfringens, and Staphylococcus aureus.艰难梭菌、产气荚膜梭菌和金黄色葡萄球菌所致抗生素相关性腹泻的患病率、危险因素及分子流行病学的比较分析
J Clin Microbiol. 2006 Aug;44(8):2785-91. doi: 10.1128/JCM.00165-06.
4
Human Food Poisoning Due to Growth of Clostridium perfringens (C. welchii) in Freshly Cooked Chicken: Preliminary Note.新鲜烹制鸡肉中产气荚膜梭菌（韦氏梭菌）生长导致的人类食物中毒：初步报告
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Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates.A型产气荚膜梭菌非食源性人类胃肠道疾病分离株中肠毒素编码质粒的全序列测定及多样性分析
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Detection and quantification of four species of the genus Clostridium in infant feces.婴儿粪便中四种梭菌属菌种的检测与定量分析。
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Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene.携带质粒肠毒素基因的A型产气荚膜梭菌人类胃肠道疾病分离株中β2毒素产生的关联。
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Detection of enterotoxigenic Clostridium perfringens type A isolates in American retail foods.在美国零售食品中检测A型产肠毒素产气荚膜梭菌分离株。
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健康北美人群粪便中产气荚膜梭菌毒素基因型

Clostridium perfringens toxin genotypes in the feces of healthy North Americans.

作者信息

Carman Robert J, Sayeed Sameera, Li Jihong, Genheimer Christopher W, Hiltonsmith Megan F, Wilkins Tracy D, McClane Bruce A

机构信息

TechLab, Inc., Blacksburg, VA 24060-6358, USA.

出版信息

Anaerobe. 2008 Apr;14(2):102-8. doi: 10.1016/j.anaerobe.2008.01.003. Epub 2008 Feb 7.

DOI:10.1016/j.anaerobe.2008.01.003
PMID:18353695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2444017/
Abstract

We investigated the frequency of Clostridium perfringens in the normal fecal flora of healthy North Americans. About half of 43 subjects were colonized with C. perfringens at levels of approximately 10(6)cfu/g feces. Only type A strains were recovered. Spores sometimes outnumbered vegetative cells. Several genotypes were found. Some donors carried two genotypes, some only one. We found no alpha, beta2 or enterotoxin in the stools of any donors. Though some isolates carried toxin genes (e.g. cpe and cpb2) on plasmids, we saw no indication that healthy humans are the reservoir for the chromosomally-borne cpe recovered from cases of C. perfringens food poisoning.

摘要

我们调查了北美健康人群正常粪便菌群中产气荚膜梭菌的频率。43名受试者中约有一半被产气荚膜梭菌定植，粪便中该菌水平约为10⁶ cfu/g。仅分离出A型菌株。孢子数量有时超过营养细胞。发现了几种基因型。一些供体携带两种基因型，一些仅携带一种。我们在所有供体的粪便中均未发现α毒素、β2毒素或肠毒素。尽管一些分离株在质粒上携带毒素基因（如cpe和cpb2），但我们没有发现任何迹象表明健康人是从产气荚膜梭菌食物中毒病例中分离出的染色体携带的cpe的储存宿主。