Hendriksen Joseph G M, Vles Johan S H
Kempenhaeghe Epilepsy Centre, Department of Behavioral Sciences, PO Box 61, 5590AB Heeze, The Netherlands.
J Child Neurol. 2008 May;23(5):477-81. doi: 10.1177/0883073807309775. Epub 2008 Mar 19.
Using a questionnaire-based study, we assessed the parent-reported prevalence of attention-deficit hyperactivity disorders (ADHDs), autism spectrum disorders, and obsessive-compulsive disorders in a group of 351 males with Duchenne muscular dystrophy. Of the 351 males with Duchenne muscular dystrophy, 11.7% were reported to have a comorbid diagnosis of ADHD, 3.1% had autism spectrum disorder, and 4.8% had obsessive-compulsive disorder. It can be concluded that the incidence of these neuropsychiatric disorders is higher in Duchenne males than in the normal population. This finding, together with recent reports on the higher prevalence of cognitive and learning problems in Duchenne, supports the view that Duchenne muscular dystrophy is not only a muscular disorder but also a disorder affecting the brain. It is important for clinical practice to take in account this heightened association. More research is needed to examine this association and its consequences.
我们采用基于问卷的研究方法，评估了351名杜氏肌营养不良男性患者中，家长报告的注意力缺陷多动障碍（ADHD）、自闭症谱系障碍和强迫症的患病率。在这351名杜氏肌营养不良男性患者中，据报告11.7%患有ADHD共病诊断，3.1%患有自闭症谱系障碍，4.8%患有强迫症。可以得出结论，这些神经精神障碍在杜氏男性中的发病率高于正常人群。这一发现，连同近期关于杜氏患者认知和学习问题患病率较高的报告，支持了杜氏肌营养不良不仅是一种肌肉疾病，也是一种影响大脑的疾病的观点。临床实践中考虑到这种更强的关联性很重要。需要更多研究来检验这种关联性及其后果。
