Barattin Régis, Voyer Normand
CEA-LETI, Laboratoire de Fonctionnalisation et Chimie pour les Microsystèmes, 17 rue des Martyrs, F-38054 Grenoble cedex 9, France.
Chem Commun (Camb). 2008 Apr 7(13):1513-32. doi: 10.1039/b614328h. Epub 2008 Feb 29.
The use of AFM to study molecular recognition events at an incredible level of sensitivity is currently a very active field of research. In order to get information at the single molecule level, it is mandatory to modify in a precise manner the AFM tip to anchor either ligand or receptor molecules. In the following lines, we review the achievements in tip modifications and illustrate the scope and limitations of the different strategies that have been reported.
利用原子力显微镜以令人难以置信的灵敏度研究分子识别事件，目前是一个非常活跃的研究领域。为了在单分子水平获取信息，必须精确修饰原子力显微镜探针，以固定配体或受体分子。在接下来的内容中，我们将回顾探针修饰方面的成果，并阐述已报道的不同策略的适用范围和局限性。
