Shayah A, Agada F O, Karsai L, Stafford N
Department of Otolaryngology and Head and Neck Surgery, Hull Royal Infirmary, Hull HU3 2JZ, United Kingdom.
Ann Afr Med. 2007 Dec;6(4):190-3. doi: 10.4103/1596-3519.55698.
Rhabdomyosarcoma is relatively seen in the pediatric age group with the head and neck region as the commonest site. To the best of our knowledge, few cases of laryngeal involvement in adult have been described in the literature. Biologically, rhabdomyosarcoma is different from squamous cell carcinoma, which is the commonest tumor of the larynx. A previously healthy non-smoker 77-year-old lady presented to the ENT outpatient with a six weeks history of intermittent alteration of voice quality. She had no history of sore throat, or any symptoms suggesting laryngo-pharyngeal reflux. Examination showed asymmetry of the left arytenoid cartilage and aryepiglottic fold. She subsequently had a direct laryngoscopy and biopsy. Histology and immunohistochemistry examination suggested the diagnosis of mesenchymal neoplasm. Following discussion at MDT she subsequently had a total laryngectomy. Histology confirmed a completely excised laryngeal rhabdomyosarcoma. Rhabdomyosarcoma of larynx in adult is a rare disease. Surgical treatment with or without adjuvant radiotherapy is currently the treatment of choice for this disease.
横纹肌肉瘤相对多见于儿童年龄组，头颈部是最常见的发病部位。据我们所知，文献中很少描述成人喉部受累的病例。从生物学角度来看，横纹肌肉瘤与喉最常见的肿瘤——鳞状细胞癌不同。一位77岁、既往健康的非吸烟女性因声音质量间歇性改变6周就诊于耳鼻喉科门诊。她没有咽痛病史，也没有任何提示喉咽反流的症状。检查发现左侧杓状软骨和杓会厌襞不对称。随后她接受了直接喉镜检查和活检。组织学和免疫组化检查提示间叶性肿瘤的诊断。在多学科团队讨论后，她随后接受了全喉切除术。组织学证实为完全切除的喉部横纹肌肉瘤。成人喉部横纹肌肉瘤是一种罕见疾病。目前，手术治疗联合或不联合辅助放疗是该病的首选治疗方法。
