Garbino Jorge, Inoubli Sarra, Mossdorf Erik, Weber Rainer, Tamm Michael, Soccal Paola, Aubert John-David, Bridevaux Pierre-Olivier, Tapparel Caroline, Kaiser Laurent
Division of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland.
AIDS. 2008 Mar 30;22(6):701-5. doi: 10.1097/QAD.0b013e3282f470ac.
To assess the incidence and epidemiological pattern of respiratory viruses in HIV-infected patients and to evaluate their potential clinical impact.
A prospective population-based cohort study was conducted at three Swiss university hospitals. Study participants were HIV-infected patients who underwent a bronchoalveolar lavage to rule out an opportunistic event. All bronchoalveolar lavage specimens were screened using a set of real-time reverse transcriptase-polymerase chain reaction assays targeting 17 different respiratory viruses.
Between November 2003 and November 2006, 59 bronchoalveolar episodes from 55 HIV-infected patients were analysed. Eleven of 59 episodes (18.6%) were positive for at least one respiratory virus. Coronavirus OC43 was identified in three cases (27.3%) followed by influenza A in two (18.2%). Parainfluenza virus (PIV) 2, PIV 3, PIV 4, bocavirus, human rhinovirus A and human metapneumovirus were each identified in one case (9%). In the majority of these cases (63.6%) no other concomitant microorganism was isolated.
Clinical investigation of respiratory viral infections in HIV-infected patients should not be restricted to prototype viruses and also need to target all the different family of viruses as it seems likely that these viruses contribute to pulmonary complications and morbidity in this population.
评估HIV感染患者中呼吸道病毒的发病率和流行病学模式，并评估其潜在的临床影响。
在瑞士的三家大学医院进行了一项基于人群的前瞻性队列研究。研究参与者为接受支气管肺泡灌洗以排除机会性感染事件的HIV感染患者。所有支气管肺泡灌洗标本均使用一组针对17种不同呼吸道病毒的实时逆转录聚合酶链反应检测方法进行筛查。
在2003年11月至2006年11月期间，对55例HIV感染患者的59次支气管肺泡灌洗事件进行了分析。59次事件中有11次（18.6%）至少有一种呼吸道病毒呈阳性。3例（27.3%）检测出冠状病毒OC43，其次是2例（18.2%）甲型流感病毒。副流感病毒（PIV）2、PIV 3、PIV 4、博卡病毒、人鼻病毒A和人偏肺病毒各有1例（9%）被检测出。在这些病例中的大多数（63.6%）未分离出其他伴随微生物。
对HIV感染患者呼吸道病毒感染的临床调查不应局限于典型病毒，还需要针对所有不同病毒家族，因为这些病毒似乎可能导致该人群的肺部并发症和发病率。
