Posada-Vergara María Paulina, Alzate-Ángel Juan Carlos, Martínez-Buitrago Ernesto
Grupo VIHCOL, Cali, Colombia.
Corporación para Investigaciones Biológicas, Unidad de Investigación Clínica. Medellin, Colombia.
Colomb Med (Cali). 2020 Jun 30;51(2):e4327. doi: 10.25100/cm.v51i2.4327.
Throughout the COVID-19 pandemic, the main risk factors associated with the progression to severe disease or death have been typically advanced age, diabetes mellitus, obesity, high blood pressure, heart disease, and chronic pneumopathy. Because of their immunosuppression status, persons with HIV were also expected to have a higher susceptibility to infection or a poor clinical evolution. So far, this has not been confirmed to happen, giving way to hypotheses about the role of immunosuppression or the use of antiretrovirals, which could explain this paradox. In this article we present the existing data on the epidemiology and characteristics of HIV-COVID-19 co-infection, discuss the available evidence on the possible factors involved in the evolution of individuals affected by both viruses, analyze other determinants that may negatively affect persons with HIV during the pandemic, and present recommendations for the prevention and care of COVID-19 infection in the context of HIV.
在整个新冠疫情期间，与病情进展至重症或死亡相关的主要风险因素通常包括高龄、糖尿病、肥胖、高血压、心脏病和慢性肺病。由于感染艾滋病毒者的免疫抑制状态，他们也被认为更容易感染或临床病情发展较差。到目前为止，尚未证实这种情况会发生，这引发了关于免疫抑制作用或抗逆转录病毒药物使用的假说，这些假说可以解释这一矛盾现象。在本文中，我们展示了关于艾滋病毒与新冠病毒合并感染的流行病学和特征的现有数据，讨论了关于这两种病毒感染者病情发展可能涉及的因素的现有证据，分析了在疫情期间可能对艾滋病毒感染者产生负面影响的其他决定因素，并提出了在艾滋病毒背景下预防和护理新冠病毒感染的建议。
