Zivković Vesna, Katić Vuka, Dordević Biljana, Krstić Miljan, Pejović Svetlana, Petrović Aleksandar
Medicinski fakultet, Institut za patologiju, Nis, Srbija.
Vojnosanit Pregl. 2007 Dec;64(12):827-31. doi: 10.2298/vsp0712827z.
BACKGROUND/AIM: A significant increase in colonic carcinoma has been analyzed in numerous clinico-pathological studies and genetics models. The aim of this study was to determinate the differences in clinico-pathological parameters of colonic carcinoma regarding localization and histological type.
The study enrolled 124 patients who had undergone surgery for colorectal carcinoma at the Clinic of Surgery in the town of Nis within 2005. Paraffin sections were stained with Hematoxilin-eosin (H&E), High iron diamine-Alcian blue (HID-AB) (pH-2.5) and Alcian blue-Preiodic arid Shiff (AB-PAS) (pH-2.5) methods. From pathological report we used data regarding: localization (right or left colon), histological type, histological grade, and parameters which determinate the tumor stage.
The total number of patients with right-sided colonic carcinoma was 40 (32.36%) and 84 (67.74%) with left-sided colonic carcinoma. Histopathologically, 96 (77.42%) adenocarcinomas and 28 (22.58%) mucinous adenocarcinomas were verified. There were no statistically significant differences between the right-sided and left-sided colonic carcinoma regarding sex, age, histological grade and tumor stage (p > 0.05). Mucinous adenocarcinomas was statistically significantly more frequent in right-sided colon (35.00%) than in left-sided colon (16.67%) (p < 0.05). There were no statistically significant differences between adenocarcinomas and mucinous adenocarcinomas regarding sex and disease stage. In younger patients the percentage of mucinous adenocarcinomas (28.57%) compared to non-mucinous ones (11.46%) was significantlly higher (p < 0.05) than in older patients. Mucinous adenocarcinomas had statistically significantly more frequently poor differentiation in comparision to adenocarcinomas (46.43% versus 9.37%, p < 0.001).
According to the presented results it can be concluded that the lower grade of differentiation of the colon adenocarcinoma and mucinous secretion are significantly often present in younger patients.
背景/目的：众多临床病理研究和遗传学模型已分析了结肠癌的显著增加。本研究的目的是确定结肠癌在定位和组织学类型方面临床病理参数的差异。
该研究纳入了2005年在尼什镇外科诊所接受结直肠癌手术的124例患者。石蜡切片采用苏木精-伊红（H&E）、高铁二胺-阿尔辛蓝（HID-AB）（pH-2.5）和阿尔辛蓝-过碘酸希夫（AB-PAS）（pH-2.5）方法染色。从病理报告中，我们使用了以下数据：定位（右半结肠或左半结肠）、组织学类型、组织学分级以及确定肿瘤分期的参数。
右半结肠癌患者总数为40例（32.36%），左半结肠癌患者为84例（67.74%）。组织病理学上，证实有96例（77.42%）腺癌和28例（22.58%）黏液腺癌。右半结肠癌和左半结肠癌在性别、年龄、组织学分级和肿瘤分期方面无统计学显著差异（p>0.05）。黏液腺癌在右半结肠（35.00%）的发生率在统计学上显著高于左半结肠（16.67%）（p<0.05）。腺癌和黏液腺癌在性别和疾病分期方面无统计学显著差异。与老年患者相比，年轻患者中黏液腺癌的百分比（28.57%）显著高于非黏液腺癌（11.46%）（p<0.05）。与腺癌相比，黏液腺癌的低分化在统计学上显著更常见（46.43%对9.37%，p<0.001）。
根据呈现的结果可以得出结论，结肠腺癌的低分化程度和黏液分泌在年轻患者中显著更常出现。
