Lanza G, Gafà R, Dubini A, Maestri I, Cavazzini L
Istituto di Anatomia, Università di Ferrara.
Pathologica. 1995 Dec;87(6):631-9.
The clinical, pathological and biologic features of 79 mucinous colorectal carcinomas were compared with those of 602 non-mucinous adenocarcinomas. The two groups did not show appreciable differences in patients' age, stage distribution, extent of lymph node involvement, grade of differentiation, pattern of growth and venous invasion. Mucinous carcinomas occurred more frequently among female patients (P < 0.05) and in the proximal colon (P < 0.01). Moreover, mucinous carcinomas more often demonstrated origin within villous adenomas (P < 0.0001) and lacked pronounced peritumoural lymphocytic infiltration (P < 0.001). A strong association was found between tumour type and flow cytometric nuclear DNA content. A high proportion of mucinous carcinomas showed DNA index (DI) values < or = 1.20 (26/38, 68.4%); conversely only 103 of 322 (32%) non-mucinous carcinomas had a DI < or = 1.20 (P < 0.0001). In addition mucinous carcinomas were characterized by infrequent p53 overexpression (4/21, 19% versus 120/183, 65.6%; P < 0.001) and higher levels of proliferative activity (P < 0.0001) compared to non-mucinous adenocarcinomas. Our data support the hypothesis that mucinous carcinoma represents a distinct clinicopathologic and genetic entity.
将79例黏液性结直肠癌的临床、病理和生物学特征与602例非黏液性腺癌的特征进行了比较。两组在患者年龄、分期分布、淋巴结受累程度、分化程度、生长模式和静脉侵犯方面未显示出明显差异。黏液性癌在女性患者中更常见（P < 0.05），且在近端结肠中更常见（P < 0.01）。此外，黏液性癌更常起源于绒毛状腺瘤（P < 0.0001），且缺乏明显的肿瘤周围淋巴细胞浸润（P < 0.001）。发现肿瘤类型与流式细胞术检测的核DNA含量之间存在密切关联。高比例的黏液性癌显示DNA指数（DI）值≤1.20（26/38，68.4%）；相反，322例非黏液性癌中只有103例（32%）的DI≤1.20（P < 0.0001）。此外，与非黏液性腺癌相比，黏液性癌的特征是p53过表达不常见（4/21，19%对120/183，65.6%；P < 0.001）且增殖活性水平较高（P < 0.0001）。我们的数据支持黏液性癌代表一种独特的临床病理和遗传实体这一假说。
